Why the study?
Does the combination of Ang II, high-sodium diet, and cold exposure affect blood pressure and structural vascular changes in male Sprague-Dawley rats?
Population
Male Sprague-Dawley rats
Comparison
Subpressor dose of Ang II (50 ng. kg. min SC)… vs Sham operation and treatment (control)
Design
Preclinical
Follow-up
12 weeks
Authors
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Salt augments Ang II but blunts cold effects on BP and remodeling in rats; hypothesis-generating and should not inform practice.
Does the combination of Ang II, high-sodium diet, and cold exposure affect blood pressure and structural vascular changes in male Sprague-Dawley rats?
A high-sodium diet potentiates the hypertensinogenic and vascular trophic effects of Ang II, but surprisingly induces hypotension and reduced vascular wall-to-lumen ratios when combined with cold stress in rats.
Simon et al. (2001) studied this question.
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