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June 1, 1995Journal of Hypertension

Angiotensin II induces cardiovascular hypertrophy in perindopril-treated rats

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Population

Immature (7-week-old) and mature (14-week-old) spontaneously hypertensive rats

Comparison

Angiotensin converting enzyme inhibitor plus… vs Angiotensin converting enzyme inhibitor plus…

Design

Preclinical

Follow-up

6 to 8 weeks

Authors

MBM. Jane BlackEast Carolina UniversityJBJohn F. BertramAustralian Regenerative Medicine InstituteJCJulie H. CampbellBuffalo State University

Discussion

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Overview

Ang II may drive hypertrophy beyond BP effects in rats; leaves open translation to human hypertension therapy.

Structured PICO

P
Population
Immature (7-week-old) and mature (14-week-old) spontaneously hypertensive rats
I
Intervention
Angiotensin converting enzyme inhibitor (perindopril) plus pressor dose of Angiotensin II infusion for 8 weeks (immature) or 6 weeks (mature)
C
Comparator
Angiotensin converting enzyme inhibitor (perindopril) plus noradrenaline infusion, or perindopril alone
O
Outcome
Vascular smooth muscle cell growth in the aorta and mesenteric arterioles, and cardiac hypertrophysurrogate

Angiotensin II directly stimulates cardiac and vascular hypertrophy independently of its blood pressure-elevating effects in a hypertensive rat model.

Cite This Study

Black et al. (1995) studied this question.

synapsesocial.com/papers/6a9240c10e9b60bc4641e256https://doi.org/10.1097/00004872-199506000-00016
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II, sodium, and cardiovascular hypertrophy in spontaneously hypertensive rats.1993 · 39 citations
  2. 2Angiotensin II causes vascular hypertrophy in part by a non-pressor mechanism.1991 · 397 citations
  3. 3Role of angiotensin II in early cardiovascular growth and vascular amplifier development in spontaneously hypertensive rats1997 · 5 citations
  4. 4Role of α<sub>1D</sub>‐adrenoceptors in vascular wall hypertrophy during angiotensin<scp>II</scp>‐induced hypertension2015 · 21 citations
  5. 5Subpressor angiotensin II is a bifunctional growth factor of vascular muscle in rats1992 · 31 citations