What question did this study set out to answer?

The study aims to explore how circulating angiotensin II influences early heart failure progression and related physiological changes.

January 1, 2000AJP Regulatory Integrative and Comparative Physiology

Influence of angiotensin on the early progression of heart failure

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Why the study?

Does high physiological plasma ANG II mediate changes in hemodynamics, salt/water balance, and neurohormonal activation in a dog model of pacing-induced heart failure?

Population

Six dogs subjected to 14 days of rapid ventricular pacing to model early progression of heart failure

Comparison

High physiological levels of plasma ANG II via… vs Approximately normal levels of plasma ANG II via…

Design

Preclinical

Follow-up

14 days

Authors

TLThomas E. LohmeierJackson Memorial Hospital HMH. L. MizelleOrlando Regional Medical Center GRGlenn A. ReinhartBoehringer Ingelheim (Taiwan)

Discussion

Member takes

Implication

High ANG II may drive decompensation in experimental HF; leaves open clinical translation and therapeutic targeting.

Key Points

The study aims to explore how circulating angiotensin II influences early heart failure progression and related physiological changes.
Six dogs underwent 14 days of rapid ventricular pacing at 240 beats/min.
Plasma ANG II levels were controlled via infusion of captopril and ANG II at normal and high physiological concentrations.
Key metrics included systemic and renal hemodynamics, alongside salt and water retention assessments.
During initial pacing, cardiac output and mean arterial pressure dropped to approximately 55% and 75% of control, respectively.
Sustained plasma ANG II at normal levels increased total peripheral resistance to 135% of control and filtration fraction to 118% of control.
At high ANG II infusion levels, only right atrial pressure increased, with notable antinatriuretic and sympathoexcitatory responses.

Structured PICO

Does high physiological plasma ANG II mediate changes in hemodynamics, salt/water balance, and neurohormonal activation in a dog model of pacing-induced heart failure?

Population

Six dogs subjected to 14 days of rapid ventricular pacing (240 beats/min) to model early progression of heart failure

Intervention

High physiological levels of plasma ANG II (days 9-12) via infusion of captopril + ANG II

Comparator

Approximately normal levels of plasma ANG II (days 1-8, 13-14) via infusion of captopril + ANG II

Outcome

Changes in systemic and renal hemodynamics, salt and water balance, and neurohormonal activationsurrogate

Increased plasma levels of ANG II play a critical role in the spontaneous transition from compensated to decompensated heart failure by inducing antinatriuretic, sympathoexcitatory, and dipsogenic responses.

Cite This Study

Lohmeier et al. (2000) studied this question.

synapsesocial.com/papers/6a209d6f2e0ff4ae796d877c https://doi.org/10.1152/ajpregu.2000.278.1.r74

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Influence of angiotensin on the early progression of heart failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Influence of angiotensin on the early progression of heart failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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