Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
September 1, 1996Hypertension

Angiotensin II in the Evolution of Experimental Heart Failure

View Full Paper
Ask AI
Bookmark
Share

Population

Canine model of rapid ventricular pacing-induced heart failure

Comparison

Rapid ventricular pacing-induced heart failure… vs Control dogs and early left ventricular…

Design

Preclinical

Authors

ALAndreas LuchnerTSTracy L. StevensDBDaniel D. Borgeson

Discussion

Loading...

Member takes

Overview

Local Ang II elevation marks overt but not early experimental HF; leaves open its relevance to human progression and therapy timing.

Structured PICO

P
Population
Canine model of rapid ventricular pacing-induced heart failure (control, early left ventricular dysfunction, and overt congestive heart failure dogs)
I
Intervention
Rapid ventricular pacing-induced heart failure progression
C
Comparator
Control dogs and early left ventricular dysfunction dogs
O
Outcome
Circulating, renal, cardiac, and vascular Angiotensin II levelssurrogate

Increased myocardial and renal Angiotensin II are hallmarks of overt experimental congestive heart failure, but these increases do not occur during early left ventricular dysfunction.

Cite This Study

Luchner et al. (1996) studied this question.

synapsesocial.com/papers/6a73967b1aa2fc9e78fb6af4https://doi.org/10.1161/01.hyp.28.3.472
View Full Paper
Ask AI
Bookmark
Share