November 1, 1993Cardiovascular Research
Selective and time related activation of the cardiac renin-angiotensin system after experimental heart failure: relation to ventricular function and morphology
Population
31 normotensive male Wistar rats (17 with experimental infarction, 14 sham operated)
Comparison
Experimental infarction to induce heart failure vs Sham operation
Design
Preclinical
Follow-up
Up to 80 days (3, 5, or 80 days)
Authors
Discussion
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Implication
May support early ACEi rationale in experimental HF; leaves open translation to clinical practice.
Structured PICO
P
Population
31 normotensive male Wistar rats (17 with experimental infarction, 14 sham operated)
I
Intervention
Experimental infarction to induce heart failure
C
Comparator
Sham operation
O
Outcome
Changes in activity of cardiac, renal, and plasma angiotensin converting enzyme (ACE) at 3, 5, or 80 days after infarction, with simultaneous measurements of left ventricular pressure, systolic dP/dt, and inner ventricular radiussurrogate
Cardiac ACE is activated early after experimental heart failure and correlates with the degree of ventricular dysfunction, providing a rationale for early ACE inhibitor therapy.
Cite This Study
Pinto et al. (1993) studied this question.