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January 1, 1996Japanese Circulation Journal-english EditionOpen Access

Cardiac Angiotensin Converting Enzyme and Endothelin Receptor in Rats With Chronic Myocardial Infarction

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Population

Rats with chronic myocardial infarction induced by left coronary ligation

Comparison

Myocardial infarction induced by left coronary… vs Sham-operated controls

Design

Preclinical

Follow-up

1 or 8 months

Authors

MKMasahiro KohzukiTohoku UniversityMKMasayuki KanazawaTohoku UniversityKYKazunori YoshidaOkayama University

Discussion

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Implication

Supports ACE role in rat post-MI repair; leaves open human relevance and therapeutic targeting.

Structured PICO

P
Population
Rats with chronic myocardial infarction induced by left coronary ligation
I
Intervention
Myocardial infarction induced by left coronary ligation
C
Comparator
Sham-operated controls
O
Outcome
Changes in cardiac angiotensin converting enzyme (ACE) and endothelin-1 (ET-1) receptor quantified by computerized in vitro autoradiographysurrogate

In a rat model of chronic myocardial infarction, cardiac ACE expression increases in infarcted and hypertrophied myocardium, suggesting a role in tissue repair and hypertrophy, while ET-1 receptors remain unchanged.

Cite This Study

Kohzuki et al. (1996) studied this question.

synapsesocial.com/papers/6a8b04aec716e89f35decfbahttps://doi.org/10.1253/jcj.60.972

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac Hypertrophy and Salt Status in Chronic Myocardial Infarction in the Rat1988 · 12 citations
  2. 2Atrial natriuretic peptide in chronic heart failure in the rat: a correlation with ventricular dysfunction.1986 · 82 citations
  3. 3Cardiomegaly and Vasoactive Hormones in Rats with Chronic Myocardial Infarction: Long-Term Effects of Chlorothiazide1996 · 10 citations
  4. 4Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes.1991 · 506 citations
  5. 5Myocardial infarct size and ventricular function in rats.1979 · 1,283 citations