Why the study?
Does central or peripheral administration of enalaprilat improve autonomic dysregulation in rats with congestive heart failure?
Population
Rats with heart failure (HF) induced by coronary artery ligation and sham-operated control (SHAM) rats
Comparison
Chronic third cerebral ventricle or… vs Vehicle (VEH) infusion
Design
Preclinical
Follow-up
28 days
Authors
Loading...
Central ACE inhibition merits exploration for HF autonomic control; animal results leave clinical translation open.
Does central or peripheral administration of enalaprilat improve autonomic dysregulation in rats with congestive heart failure?
Central, but not peripheral, administration of a low-dose ACE inhibitor prevents autonomic dysregulation in a rat model of heart failure, highlighting the critical role of the brain renin-angiotensin system.
Francis et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: