Key result
Experimental myocardial infarction in rats decreased lung ACE activity (P<.0001) and increased plasma ACE activity (P<.01) compared to sham-operated controls.
Why the study?
Does experimental congestive heart failure alter pulmonary and plasma ACE activity in Wistar rats?
Population
Wistar rats 3 months after induction of myocardial infarction (MI) and sham-operated (control) rats
Comparison
Induction of myocardial infarction to cause… vs Sham-operated (control) rats
Design
Preclinical
Follow-up
3 months
Authors
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Experimental HF alters ACE distribution in rats; leaves open human translation and clinical relevance.
Does experimental congestive heart failure alter pulmonary and plasma ACE activity in Wistar rats?
p-value: p=<.0001
In experimental congestive heart failure, lung ACE activity and mRNA levels decrease while plasma ACE activity increases, representing a novel aspect of endothelial dysfunction.
Huang et al. (1994) studied Congestive heart failure. Myocardial infarction (experimental CHF) vs. Sham-operated (control) rats was evaluated on Lung and plasma ACE activity (p=<.0001). Experimental myocardial infarction in rats decreased lung ACE activity (P<.0001) and increased plasma ACE activity (P<.01) compared to sham-operated controls.
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