Why the study?
Does chronic benazepril administration improve cardiac output and fluid balance in dogs with pacing-induced heart failure?
Population
11 dogs with heart failure produced by rapid ventricular pacing
Comparison
Chronic benazepril administration vs Normally functioning renin-angiotensin system
Design
Preclinical
Follow-up
7 to 21 days
Authors
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Supports early experimental HF research; leaves clinical translation in dogs or humans open.
Does chronic benazepril administration improve cardiac output and fluid balance in dogs with pacing-induced heart failure?
Chronic ACE inhibition with benazepril improves cardiac output and fluid balance in early stages of pacing-induced heart failure in dogs, but is less effective in decompensated stages.
Brands et al. (1993) studied this question.
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