Why the study?
Does direct renin inhibition with CP80794 improve hemodynamics and peripheral blood flows compared to captopril in dogs with pacing-induced heart failure?
Population
Conscious chronically instrumented dogs with advanced congestive heart failure induced by 4-7 weeks of rapid…
Comparison
Direct renin inhibition with CP80794 3 mg/kg i.v. vs Angiotensin converting enzyme inhibition with…
Design
Preclinical
Authors
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May support renal hemodynamic advantages of direct renin inhibition in experimental HF; leaves open translation to clinical practice.
Does direct renin inhibition with CP80794 improve hemodynamics and peripheral blood flows compared to captopril in dogs with pacing-induced heart failure?
In a canine model of pacing-induced heart failure, direct renin inhibition with CP80794 produced similar systemic hemodynamic improvements as captopril but significantly greater increases in renal blood flow.
Richard P. Shannon (1997) studied this question.
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