Key result
Captopril enhances renal vasodilation compared to EXP 3174 in anesthetized dogs.
Why the study?
The comparative effects of ACE inhibition with captopril and angiotensin II receptor blockade with EXP 3174 on renal glomerular hemodynamics were not fully characterized.
Does the addition of captopril to EXP 3174 provide enhanced renal vasodilatory effects compared to EXP 3174 alone in anesthetized dogs?
Population
Anesthetized dogs
Comparison
EXP 3174 alone vs EXP 3174 plus captopril with or without Hoe 140
Design
Preclinical experimental study
Authors
Loading...
Should not yet influence ACE inhibitor versus ARB selection in patients; leaves open differential renal vasodilation in humans.
Does the addition of captopril to EXP 3174 provide enhanced renal vasodilatory effects compared to EXP 3174 alone in anesthetized dogs?
ACE inhibitors provide enhanced renal vasodilation compared to ARBs in dogs, an effect that appears to be mediated by kinins.
Heller et al. (1997) studied this question. EXP 3174 and captopril was evaluated on Renal glomerular hemodynamics. Administration of the ACE inhibitor captopril led to a significantly enhanced vasodilatory response in the kidney compared with the angiotensin II-receptor blocker EXP 3174 in anesthetized dogs.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: