Key result
Captopril decreased arterial pressure and renal vascular resistance while increasing renal blood flow and glomerular filtration rate in sodium-restricted dogs, primarily due to diminished angiotensin II activity.
Authors
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May guide ACEI use in sodium-depleted states; leaves open human translation.
Carmines et al. (1983) studied Anesthetized sodium-restricted dogs (n=12). Captopril vs. Baseline / Angiotensin II / Indomethacin was evaluated on Arterial pressure, glomerular filtration rate, renal blood flow, and renal vascular resistance. Captopril decreased arterial pressure and renal vascular resistance while increasing renal blood flow and glomerular filtration rate in sodium-restricted dogs, primarily due to diminished angiotensin II activity.
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