Why the study?
Does intravenous captopril affect systemic blood pressure, renal blood flow, and renal vascular resistance in pentobarbital anesthetized dogs?
Population
Pentobarbital anesthetized dogs (untreated and with partially occluded renal artery)
Comparison
Captopril 1 mg/kg administered intravenously vs Baseline in both untreated dogs and dogs with…
Design
Preclinical
Authors
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May guide ACE inhibitor research in renovascular models; leaves open clinical translation from this animal study.
Does intravenous captopril affect systemic blood pressure, renal blood flow, and renal vascular resistance in pentobarbital anesthetized dogs?
The vasodilator effect of captopril is enhanced under conditions of increased circulating angiotensin II, such as renal artery occlusion.
Satoh et al. (1980) studied this question.
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