January 1, 1991AJP Heart and Circulatory Physiology
Renal sympathetic nerve and hemodynamic responses to captopril in conscious dogs: role of prostaglandins
Why the study?
Does captopril alter the relationship between arterial pressure, heart rate, and renal sympathetic nerve activity in conscious dogs, and is this mediated by prostaglandins?
Population
22 conscious, quietly resting, instrumented dogs
Comparison
Captopril 2 mg/kg IV vs Sodium nitroprusside infusion or pretreatment…
Design
Preclinical
Follow-up
10 minutes
Authors
Discussion
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Implication
Hypothesis-generating for prostaglandin-mediated sympathoinhibition by captopril; human studies needed before clinical relevance.
Structured PICO
Does captopril alter the relationship between arterial pressure, heart rate, and renal sympathetic nerve activity in conscious dogs, and is this mediated by prostaglandins?
P
Population
22 conscious, quietly resting, instrumented dogs
I
Intervention
Captopril 2 mg/kg IV
C
Comparator
Sodium nitroprusside infusion (to lower arterial pressure) or pretreatment with cyclooxygenase inhibitor (indomethacin or meclofenamate) before captopril
O
Outcome
Changes in arterial pressure, heart rate, and renal sympathetic nerve activity at 10 minutes post-administrationsurrogate
Captopril induces sympathoinhibition in conscious dogs despite lowering arterial pressure, an effect that appears to be mediated by augmented prostaglandin synthesis.
Cite This Study
Zucker et al. (1991) studied this question.