Key result
Captopril significantly reduced background sympathetic discharge (from 2.7 to 0.79 imp/0.1 s; P<0.01) and its responsiveness to excitatory stimuli in cats, likely via a brain stem site of action.
Absolute Event Rate: 0.79% vs 2.7%
p-value: p=< 0.01
Captopril reduces sympathetic efferent activity and responsiveness to excitatory stimuli via a brain stem site of action in feline models.
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Cautions against clinical extrapolation from feline data; leaves open central sympathoinhibitory roles for ACE inhibitors in human disease.
Montano et al. (1993) studied this question. captopril vs. baseline was evaluated on background discharge of thoracic preganglionic sympathetic fibers (p=< 0.01). Captopril significantly reduced background sympathetic discharge (from 2.7 to 0.79 imp/0.1 s; P<0.01) and its responsiveness to excitatory stimuli in cats, likely via a brain stem site of action.
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