Why the study?
Does intravenous captopril alter systemic blood pressure, renal blood flow, and renal vascular resistance in anesthetized dogs?
Population
Pentobarbital anesthetized dogs (some with intact renal artery, others with partially occluded renal artery)
Comparison
Captopril administered intravenously at a dose… vs Baseline/untreated state and comparison between…
Design
Preclinical
Authors
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Captopril's renal effects may be enhanced with elevated angiotensin II in dogs; leaves open translation to human renovascular disease.
Does intravenous captopril alter systemic blood pressure, renal blood flow, and renal vascular resistance in anesthetized dogs?
The vasodilator effect of captopril depends on the background level of angiotensin II, with enhanced effects seen when circulating angiotensin II is elevated.
Satoh et al. (1980) studied this question.
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