Key result
IV captopril increases renal artery blood flow and decreases vascular resistance despite indomethacin pretreatment.
Why the study?
Does captopril cause renal vasodilation via a prostaglandin-dependent mechanism in anesthetized dogs?
Population
Pentobarbital anesthetized dogs
Comparison
Captopril administered intravenously following… vs Control dogs receiving captopril without…
Design
Preclinical
Authors
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Captopril renal vasodilation is prostaglandin-independent in dogs; leaves open human mechanism and clinical relevance.
Does captopril cause renal vasodilation via a prostaglandin-dependent mechanism in anesthetized dogs?
Captopril induces renal vasodilation through a mechanism independent of prostaglandins in a canine model.
Tobia et al. (1981) studied Pentobarbital anesthetized dogs. Captopril vs. Control dogs (no indomethacin) was evaluated on Renal artery blood flow and renal vascular resistance. Intravenous captopril caused significant dose-related increases in renal artery blood flow and decreases in renal vascular resistance, which were not attenuated by indomethacin pretreatment.
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