Key result
Captopril therapy partially preserved the ability of myocytes to shorten and relengthen after myocardial infarction, accompanied by decreased lateral and longitudinal cell expansion.
Why the study?
Does captopril improve the mechanical performance of spared myocytes after myocardial infarction in rats?
Population
Rats with myocardial infarction-induced left ventricular failure via coronary arterial occlusion
Comparison
Captopril administered immediately after surgery vs Untreated rats with myocardial infarction
Design
Preclinical
Follow-up
7 days
Authors
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Early captopril may aid post-MI myocyte preservation in rats; leaves open translation to human therapy.
Does captopril improve the mechanical performance of spared myocytes after myocardial infarction in rats?
In a rat model of myocardial infarction, early captopril treatment partially preserves the contractile function of spared myocytes and attenuates pathological cellular hypertrophy.
Capasso et al. (1992) studied Myocardial infarction. Captopril vs. Untreated myocardial infarction was evaluated on Mechanical characteristics and contractile behavior of remaining viable myocytes. Captopril therapy partially preserved the ability of myocytes to shorten and relengthen after myocardial infarction, accompanied by decreased lateral and longitudinal cell expansion.
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