July 1, 1995Journal of Hypertension
The acute and chronic effects of losartan in heart failure
Why the study?
Does losartan improve haemodynamic parameters in patients with heart failure?
Population
Patients with heart failure
Design
Review
Follow-up
12 weeks
Authors
Discussion
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Member takes
Implication
Losartan may improve hemodynamics in HF; leaves open whether benefits extend to clinical outcomes in randomized trials.
Structured PICO
Does losartan improve haemodynamic parameters in patients with heart failure?
P
Population
Patients with heart failure
I
Intervention
Losartan (single dose and over 12 weeks)
O
Outcome
Haemodynamic effects (angiotensin II, aldosterone, systemic vascular resistance, systemic blood pressure, pulmonary capillary wedge pressure, heart rate, and cardiac index)surrogate
Losartan demonstrates favorable acute and chronic hemodynamic effects in patients with heart failure, supporting its potential therapeutic role.
Cite This Study
Crozier et al. (1995) studied this question.