Why the study?
Does the combination of losartan and enalapril reduce blood pressure more than doubling the dose of enalapril in sodium-depleted normotensive subjects?
Population
12 sodium-depleted normotensive subjects
Comparison
Combination of 50 mg losartan and 10 mg… vs 10 mg enalapril alone and 20 mg enalapril alone
Design
RCT, randomized, three-way crossover, double-blind
Follow-up
24 hours
Authors
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Supports greater BP reduction with losartan-enalapril than enalapril dose doubling; extends dual RAAS blockade evidence in sodium depletion.
Does the combination of losartan and enalapril reduce blood pressure more than doubling the dose of enalapril in sodium-depleted normotensive subjects?
The combination of losartan and enalapril is more effective in decreasing blood pressure and increasing plasma active renin than doubling the dose of enalapril in sodium-depleted normotensive subjects.
Azizi et al. (1997) studied this question.
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