Why the study?
Does a combination drug therapy regimen commencing with losartan compared to enalapril improve blood pressure reduction in patients with severe hypertension?
Population
75 patients, 23-74 years of age, with severe hypertension (sitting diastolic blood pressure of 115-130 mmHg)
Comparison
Combination drug therapy regimen commencing with… vs Combination drug therapy regimen commencing with…
Design
RCT, randomized, initial treatments were blinded
Follow-up
12 weeks
Authors
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Enalapril-based therapy yields modestly greater BP reduction than losartan in severe hypertension; confirms ACEI edge while validating high ARB response rates.
Does a combination drug therapy regimen commencing with losartan compared to enalapril improve blood pressure reduction in patients with severe hypertension?
Both losartan- and enalapril-based regimens are highly effective and well-tolerated for treating severe hypertension, with enalapril showing a slightly greater but clinically small statistical advantage in blood pressure reduction.
Ruff et al. (1996) studied this question.
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