July 1, 1992Journal of Cardiovascular Pharmacology

Synergistic Effect on Reduction in Blood Pressure with Coadministration of the Renin Inhibitor, CP-80,794, and the Angiotensin Converting Enzyme Inhibitor, Captopril

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Why the study?

Does coadministration of CP-80,794 and captopril synergistically reduce blood pressure in sodium-depleted guinea pigs?

Structured PICO

Does coadministration of CP-80,794 and captopril synergistically reduce blood pressure in sodium-depleted guinea pigs?

Population

Sodium-depleted guinea pigs

Intervention

Coadministration of renin inhibitor CP-80,794 (0.3-3.0 mg/kg i.v.) and ACE inhibitor captopril (0.03-1.0 mg/kg i.v.)

Comparator

CP-80,794 alone and captopril alone

Outcome

Reduction in blood pressure (area, peak drop, and duration of change)surrogate

Coadministration of a renin inhibitor and an ACE inhibitor produces synergistic blood pressure reduction in a guinea pig model, potentially allowing for significant dose reductions.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for dose-sparing renin-ACE inhibitor combinations; human trials required before any clinical consideration.

Cite This Study

Fossa et al. (1992) studied this question.

synapsesocial.com/papers/6a8307965c109110e17d5874 https://doi.org/10.1097/00005344-199207000-00010

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Synergistic Effect on Reduction in Blood Pressure with Coadministration of the Renin Inhibitor, CP-80,794, and the Angiotensin Converting Enzyme Inhibitor, Captopril

Structured PICO

Discussion

Implication

Cite This Study

Synergistic Effect on Reduction in Blood Pressure with Coadministration of the Renin Inhibitor, CP-80,794, and the Angiotensin Converting Enzyme Inhibitor, Captopril

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider