What question did this study set out to answer?

To establish a sensitive radioimmunoassay for angiotensin I and evaluate the in vivo biochemical effects of the renin inhibitor CGP 38560A in healthy individuals pretreated with an ACE inhibitor.

March 1, 1992British Journal of Clinical PharmacologyOpen Access

Investigation of the biochemical effects of renin inhibition in normal volunteers treated by an ACE inhibitor.

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Why the study?

Does the renin inhibitor CGP 38560A reduce plasma Angiotensin I levels in healthy volunteers pre-treated with an ACE inhibitor?

Population

6 healthy volunteers pre-treated with 20 mg lisinopril to reset the renin-angiotensin system

Comparison

30 min infusion of the renin inhibitor CGP 38560A vs 5% glucose infusion

Design

RCT, randomized three-way cross-over protocol

Follow-up

short-term (following 30 min infusion)

Authors

DCDominique ChauveauCentre Hospitalier Universitaire de Toulouse TGTT GuyenneInserm FCFrédéric CuminNovartis (Switzerland)

Discussion

Member takes

Implication

Renin inhibition yields near-total Ang I suppression despite ACEI; extends dual RAAS blockade evidence to stimulated systems.

Key Points

To establish a sensitive radioimmunoassay for angiotensin I and evaluate the in vivo biochemical effects of the renin inhibitor CGP 38560A in healthy individuals pretreated with an ACE inhibitor.
Developed a solid-phase phenylsilylsilica extraction and radioimmunoassay method to quantify plasma angiotensin I with a detection limit of 0.77 fmol ml-1.
Enrolled six healthy volunteers pretreated with 20 mg lisinopril to stimulate the renin-angiotensin system, followed by a randomized three-way crossover 30-minute infusion of CGP 38560A (125 or 250 µg kg-1) or 5% glucose control.
Lisinopril administration reset the renin-angiotensin system over 24 hours, raising active plasma renin to 275% and angiotensin I to 429% of basal values.
Infusion of CGP 38560A induced a 92% reduction in plasma angiotensin I at 125 µg kg-1 and a 97.5% reduction at 250 µg kg-1, accompanied by a compensatory increase in active plasma renin.

Structured PICO

Does the renin inhibitor CGP 38560A reduce plasma Angiotensin I levels in healthy volunteers pre-treated with an ACE inhibitor?

Population

6 healthy volunteers pre-treated with 20 mg lisinopril to reset the renin-angiotensin system

Intervention

30 min infusion of the renin inhibitor CGP 38560A (125 or 250 micrograms kg-1)

Comparator

5% glucose infusion

Outcome

Plasma Angiotensin I (Ang I) levelssurrogate

Infusion of the renin inhibitor CGP 38560A profoundly reduces plasma Angiotensin I levels in healthy volunteers with an ACE-inhibitor-stimulated renin-angiotensin system.

Cite This Study

Chauveau et al. (1992) studied this question.

synapsesocial.com/papers/6a8d16ccf7e5dfc2fb2fe16b https://doi.org/10.1111/j.1365-2125.1992.tb04032.x

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Investigation of the biochemical effects of renin inhibition in normal volunteers treated by an ACE inhibitor.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Investigation of the biochemical effects of renin inhibition in normal volunteers treated by an ACE inhibitor.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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