Why the study?
Does chronic administration of the renin inhibitor CGP 29,287 reduce blood pressure in normotensive marmosets?
Population
16 normotensive marmosets fed a low-sodium diet
Design
Preclinical
Follow-up
14 days
Authors
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Chronic renin inhibition sustains BP reduction in marmosets; leaves open mechanism beyond PRA recovery for human translation.
Does chronic administration of the renin inhibitor CGP 29,287 reduce blood pressure in normotensive marmosets?
Chronic administration of a renin inhibitor produces sustained blood pressure reduction in marmosets that does not correlate with the degree of plasma renin activity inhibition over time.
Wood et al. (1987) studied this question.
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