Why the study?
Do renin inhibitors and ACE inhibitors lower blood pressure in a marmoset model of segmental renal infarction-induced hypertension?
Population
Marmosets with hypertension induced by ligating the minor branch of one renal artery (n=9)
Design
Preclinical
Follow-up
15 weeks
Authors
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Hypothesis-generating for RAS inhibition in low-renin hypertension; leaves open human translation beyond this marmoset model.
Do renin inhibitors and ACE inhibitors lower blood pressure in a marmoset model of segmental renal infarction-induced hypertension?
In a marmoset model of renal hypertension, blood pressure remains dependent on the renin-angiotensin system and responds to renin and ACE inhibition even when plasma renin activity is not elevated.
Neisius et al. (1987) studied this question.
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