Key result
Oral administration of the renin inhibitor ES-8891 for 1 week significantly decreased kidney renin mRNA content compared to normal controls (4.2 vs 12.8 pg/micrograms of total RNA; P<0.05).
Why the study?
Does the renin inhibitor ES-8891 reduce renin synthesis and secretion in normotensive sodium-depleted marmosets?
Population
Normotensive sodium-depleted marmosets (n=5 per group)
Comparison
ES-8891 60 mg/kg/day orally for 1 week vs Normal controls
Design
Preclinical
Follow-up
1 week
Authors
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Supports mechanism in marmoset model; leaves open human translation and efficacy trials.
Does the renin inhibitor ES-8891 reduce renin synthesis and secretion in normotensive sodium-depleted marmosets?
Absolute Event Rate: 4.2% vs 12.8%
p-value: p=<0.05
In a marmoset model, the renin inhibitor ES-8891 decreased both plasma renin activity and kidney renin synthesis.
Kitami et al. (1991) studied Normotensive sodium-depleted (n=10). ES-8891 vs. Normal controls was evaluated on Kidney renin mRNA content (pg/micrograms of total RNA) (p=<0.05). Oral administration of the renin inhibitor ES-8891 for 1 week significantly decreased kidney renin mRNA content compared to normal controls (4.2 vs 12.8 pg/micrograms of total RNA; P<0.05).