Why the study?
Does the renin inhibitor CGP 29,287 lower blood pressure and reduce active hormones of the renin-angiotensin system in normotensive marmosets on a low-salt diet?
Population
Normotensive marmosets fed a low-salt diet
Comparison
Renin inhibitor CGP 29,287 administered… vs Vehicle only
Design
Preclinical
Follow-up
7 days
Authors
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Does not inform clinical practice; leaves open translation of renin inhibition to human hypertension.
Does the renin inhibitor CGP 29,287 lower blood pressure and reduce active hormones of the renin-angiotensin system in normotensive marmosets on a low-salt diet?
Prolonged renin inhibition with CGP 29,287 in marmosets effectively lowers blood pressure and suppresses Ang II and aldosterone formation despite a marked compensatory increase in renin release.
Wood et al. (1989) studied this question.
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