July 1, 1987Journal of Hypertension
Inhibition of Renin-Like Activity in Marmoset Tissues by the Renin Inhibitor CGP 29 287
Why the study?
Does CGP 29 287 inhibit tissue renin-like activity in vivo in furosemide-pretreated marmosets?
Population
Furosemide-pretreated marmosets (5mg/kg, i.m.)
Comparison
CGP 29 287 (1 mg/kg, i.v. bolus injection) vs Vehicle (0.9% saline, 1 ml/kg, i.v.)
Design
Preclinical
Follow-up
30 min
Authors
Discussion
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Implication
Indicates acute renin inhibitor effects confined to circulating renin in marmosets; leaves open tissue renin's role in chronic or clinical settings.
Structured PICO
Does CGP 29 287 inhibit tissue renin-like activity in vivo in furosemide-pretreated marmosets?
P
Population
Furosemide-pretreated marmosets (5mg/kg, i.m.)
I
Intervention
CGP 29 287 (1 mg/kg, i.v. bolus injection)
C
Comparator
Vehicle (0.9% saline, 1 ml/kg, i.v.)
O
Outcome
Tissue renin-like activity (rate of angiotensin I formation) in brain, heart, aorta and kidneysurrogate
The acute hypotensive response to the renin inhibitor CGP 29 287 in marmosets appears to be mediated solely by inhibition of circulating renin, not tissue renin.
Cite This Study
Wood et al. (1987) studied this question.