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January 20, 2005Journal of Hypertension

Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats

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Why the study?

Does aliskiren lower blood pressure in animal models of hypertension?

Population

Sodium-depleted marmosets and spontaneously hypertensive rats

Comparison

Aliskiren vs Remikiren, zankiren, valsartan, benazepril, or…

Design

Preclinical

Authors

JWJeanette M. WoodUniversity of BernCSChristian SchnellStony Brook UniversityFCFrédéric CuminNovartis (Switzerland)

Discussion

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Implication

Supports aliskiren development in hypertension models; leaves open translation to human therapy.

Structured PICO

Does aliskiren lower blood pressure in animal models of hypertension?

P
Population
Sodium-depleted marmosets and spontaneously hypertensive rats
I
Intervention
Aliskiren (oral dosing 1-30 mg/kg in marmosets; subcutaneous osmotic minipumps 10-100 mg/kg per day in rats)
C
Comparator
Remikiren, zankiren, valsartan, benazepril, or benazeprilat
O
Outcome
Blood pressure and heart rate measured by radiotelemetrysurrogate

Aliskiren is an orally effective renin inhibitor that demonstrates significant and long-lasting blood pressure reduction in animal models, supporting its potential as an antihypertensive therapy.

Cite This Study

Wood et al. (2005) studied this question.

synapsesocial.com/papers/6a779d93d3a6aa87c6bddb1ehttps://doi.org/10.1097/00004872-200502000-00025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood pressure effects of acute intravenous renin or oral angiotensin converting enzyme inhibition in essential hypertension1994 · 25 citations
  2. 2RENIN INHIBITION: IMMUNOLOGICAL PROCEDURES AND RENIN INHIBITOR PEPTIDES1989 · 12 citations
  3. 3Nonparallel Effects of Renin Inhibitor Treatment on Plasma Renin Activity and Angiotensins I and II in Hypertensive Subjects1991 · 37 citations
  4. 4Additive Effects of Losartan and Enalapril on Blood Pressure and Plasma Active Renin1997 · 130 citations
  5. 5Synergistic Effect on Reduction in Blood Pressure with Coadministration of the Renin Inhibitor, CP-80,794, and the Angiotensin Converting Enzyme Inhibitor, Captopril1992 · 19 citations