Why the study?
Does aliskiren reduce blood pressure in patients with mild to moderate hypertension compared to losartan?
Population
226 patients, 21 to 70 years of age, with mild to moderate hypertension
Comparison
Aliskiren 37.5 mg, 75 mg, 150 mg, or 300 mg oral… vs Losartan 100 mg daily for 4 weeks
Design
RCT, randomly assigned, double-blind
Follow-up
4 weeks
Authors
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Aliskiren offers a comparable alternative to losartan; confirms direct renin inhibition as an effective strategy in mild-moderate hypertension.
Does aliskiren reduce blood pressure in patients with mild to moderate hypertension compared to losartan?
Aliskiren is an effective and safe orally active blood pressure-lowering agent that provides dose-dependent reductions in systolic blood pressure comparable to losartan.
Stanton et al. (2003) studied this question.
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