Key result
Aliskiren lowers BP comparably to major antihypertensives with a placebo-like side effect profile.
Why the study?
Aliskiren is the first orally active renin inhibitor approved for hypertension, but its cardiovascular benefits beyond blood pressure control remain to be demonstrated.
Is aliskiren effective and safe for lowering blood pressure in patients with hypertension?
Population
Patients with hypertension
Comparison
Aliskiren 150 mg and 300 mg versus placebo or other major antihypertensive classes
Design
Review
Authors
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Aliskiren may be considered an alternative antihypertensive; leaves open its role in outcome trials.
Is aliskiren effective and safe for lowering blood pressure in patients with hypertension?
Aliskiren is the first orally active renin inhibitor approved for clinical use, providing effective blood pressure reduction with a favorable side effect profile.
Morris Jonathan Brown (2008) conducted a review in Hypertension. Aliskiren vs. Placebo or other antihypertensive drugs was evaluated. Aliskiren at doses of 150 mg and 300 mg provides dose-related reductions in blood pressure comparable to other major antihypertensive classes, with a placebo-like side effect profile.
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