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December 30, 2006American Journal of HypertensionOpen Access

Aliskiren, an Orally Effective Renin Inhibitor, Provides Antihypertensive Efficacy Alone and in Combination With Valsartan

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Why the study?

Does aliskiren alone or in combination with valsartan reduce blood pressure in patients with mild-to-moderate hypertension?

Population

1,123 patients with mild-to-moderate hypertension

Comparison

Aliskiren monotherapy, valsartan monotherapy… vs Matching placebo administered orally once daily

Design

RCT, Randomized in a modified factorial study design, Double-blind

Follow-up

8 weeks

Authors

JPJames L. PoolAnglia Ruskin UniversityRSR. SchmiederUniversitätsklinikum ErlangenMAMichel AziziVascular Medicine

Discussion

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Implication

Supports aliskiren for BP control in mild-to-moderate hypertension; extends direct renin inhibition to ARB combinations.

Structured PICO

Does aliskiren alone or in combination with valsartan reduce blood pressure in patients with mild-to-moderate hypertension?

P
Population
1,123 patients with mild-to-moderate hypertension
I
Intervention
Aliskiren monotherapy (75, 150, or 300 mg), valsartan monotherapy (80, 160, or 320 mg), aliskiren and valsartan in combination, or valsartan/hydrochlorothiazide (160/12.5 mg) administered orally once daily for 8 weeks
C
Comparator
Matching placebo administered orally once daily
O
Outcome
Change from baseline in mean sitting diastolic blood pressure (DBP) at endpoint (8 weeks)surrogate

Aliskiren, a direct renin inhibitor, effectively lowers blood pressure both as monotherapy and in combination with valsartan, with a tolerability profile similar to placebo.

Cite This Study

Pool et al. (2006) studied this question.

synapsesocial.com/papers/6a816c78878fbc24852301ffhttps://doi.org/10.1016/j.amjhyper.2006.06.003

Topics

Hypertension management
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  4. 4Pharmacologic Demonstration of the Synergistic Effects of a Combination of the Renin Inhibitor Aliskiren and the AT1 Receptor Antagonist Valsartan on the Angiotensin II–Renin Feedback Interruption2004 · 235 citations
  5. 5Aliskiren, a Novel Orally Effective Renin Inhibitor, Provides Dose-Dependent Antihypertensive Efficacy and Placebo-Like Tolerability in Hypertensive Patients2005 · 525 citations