Why the study?
Does aliskiren reduce mean arterial blood pressure in sodium-depleted marmosets?
Population
Sodium-depleted marmosets (primates)
Design
Preclinical
Authors
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May support progression to human trials; leaves open clinical translation of oral renin inhibition from primate models.
Does aliskiren reduce mean arterial blood pressure in sodium-depleted marmosets?
The structural modification of renin inhibitors led to the discovery of aliskiren, an orally active agent that dose-dependently reduces blood pressure in primates.
Maibaum et al. (2007) studied this question.
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