Why the study?
Does the renin inhibitor RI-78 reduce mean arterial pressure comparably to the ACE inhibitor teprotide in conscious monkeys?
Population
Conscious monkeys (M. fascicularis), including salt-depleted normotensive and acute renal hypertensive models
Comparison
Renin inhibitor 375 micrograms/kg bolus injection vs Angiotensin converting enzyme inhibitor 1 mg/kg
Design
Preclinical
Follow-up
Acute (up to 15 minutes)
Authors
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Supports renin inhibitor development; leaves open translation to human hypertension.
Does the renin inhibitor RI-78 reduce mean arterial pressure comparably to the ACE inhibitor teprotide in conscious monkeys?
The renin inhibitor RI-78 demonstrates a prompt hypotensive effect comparable to the ACE inhibitor teprotide in conscious monkey models.
Takaori et al. (1987) studied this question.
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