January 1, 1985Journal of Cardiovascular Pharmacology
In Vivo Inhibition of Renin by Antirenin Antibodies
Key result
Antirenin antibodies induced systemic depressor responses and completely suppressed plasma renin and angiotensin II levels in sodium-depleted or renovascular hypertensive animals.
Why the study?
Do antirenin antibodies reduce blood pressure and suppress renin/angiotensin II levels in animal models?
Population
Dogs (sodium-replete, sodium-depleted, or with acute renovascular hypertension) and conscious monkeys
Design
Preclinical
Authors
Discussion
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Implication
Hypothesis-generating in renin-dependent models; leaves open translation to human hypertension therapy.
Structured PICO
Do antirenin antibodies reduce blood pressure and suppress renin/angiotensin II levels in animal models?
P
Population
Dogs (sodium-replete, sodium-depleted, or with acute renovascular hypertension) and conscious monkeys
I
Intervention
Antirenin antibodies (polyclonal IgG and Fab specific to dog renal renin, and monoclonal antibodies to human renal renin)
O
Outcome
Blood pressure response, plasma renin levels, and angiotensin II levelssurrogate
Antirenin antibodies effectively lower blood pressure and suppress the renin-angiotensin system in renin-dependent animal models, demonstrating potential as specific therapeutic agents.
Limitations
- Polyclonal antisera lack homogeneity, reproducibility, and are limited in quantity
Cite This Study
Victor J. Dzau (1985) studied Hypertension (animal model). Antirenin antibodies was evaluated on Blood pressure and plasma renin/angiotensin II levels. Antirenin antibodies induced systemic depressor responses and completely suppressed plasma renin and angiotensin II levels in sodium-depleted or renovascular hypertensive animals.