Why the study?
Does renin-specific IgG or Fab reduce blood pressure and plasma renin activity in dogs?
Population
Dogs (sodium-replete unanesthetized, sodium-deplete, and acute renovascular hypertensive)
Design
Preclinical
Follow-up
up to 24 hours
Authors
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Renin-specific antibodies validate target engagement in dogs; leaves open whether immunologic renin blockade merits human investigation.
Does renin-specific IgG or Fab reduce blood pressure and plasma renin activity in dogs?
Renin-specific IgG and Fab effectively reduce blood pressure and plasma renin activity in renin-dependent hypertensive and sodium-deplete dogs, demonstrating their utility in physiological studies.
Dzau et al. (1984) studied this question.
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