Why the study?
Does active immunization with mouse renin reduce blood pressure in spontaneously hypertensive and normotensive rats?
Population
Male spontaneously hypertensive Okamoto-strain rats and normotensive Wistar-Kyoto rats
Comparison
Active immunization with purified mouse… vs Immunization with bovine serum albumin
Design
Preclinical
Follow-up
up to 24 weeks
Authors
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Renin immunization normalizes BP in SHR; leaves open human translation given autoimmune nephritis risk.
Does active immunization with mouse renin reduce blood pressure in spontaneously hypertensive and normotensive rats?
Active immunization against renin effectively lowers blood pressure and suppresses the renin-angiotensin system in spontaneously hypertensive rats, but induces chronic autoimmune interstitial nephritis.
Michel et al. (1990) studied this question.
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