Population
Hypertensive transgenic rat TGR(mRen-2)27 and Sprague-Dawley rats
Comparison
Perindopril and mouse Ren-2 renin antibody vs Untreated TGR(mRen-2)27 rats
Design
Preclinical
Authors
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ACE inhibition reverses renal renin suppression in this model; confirms feedback inhibition and leaves open human translation.
In TGR(mRen-2)27 rats, low kidney renin is due to physiological feedback inhibition rather than genetic factors, as ACE inhibition with perindopril reverses the suppression.
Tokita et al. (1995) studied this question.
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