Population
Transgenic rats TGR(mRen2)27, Harlan Sprague-Dawley (SD) rats, and Hannover SD rats
Comparison
Nephrectomy (NEPEX) and adrenalectomy (ADX) vs Control levels and comparison between rat strains
Design
Preclinical
Authors
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Hypothesis-generating for adrenal renin contribution in TGR(mRen2)27 hypertension; leaves open relevance to human disease.
In transgenic TGR(mRen2)27 rats, the adrenal gland is a major source of circulating renin, though other extrarenal sources also exist.
Tokita et al. (1994) studied this question.
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