Population
Hypertensive transgenic rat model TGR27 and Sprague-Dawley control rats.
Comparison
ACTH stimulation and spironolactone treatment. vs Sprague-Dawley rats and untreated state.
Design
Preclinical
Follow-up
between 6-18 weeks of age
Authors
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Challenges mineralocorticoid-centric hypertension views in TGR rats; leaves open local intra-adrenal RAS contributions to steroid excess for translational study.
In the TGR(mREN2)27 hypertensive rat model, adrenal steroid metabolism is markedly stimulated, likely due to a local intraadrenal renin-angiotensin system, though hypertension is not solely driven by hypermineralocorticoidism.
Sander et al. (1992) studied this question.
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