Key result
Tissue-specific expression of the Ren-2 gene in TGR(mREN2)27 transgenic hypertensive rats was similar to DBA/2 mice, with expression in cardiovascular organs preceding the development of hypertension.
Authors
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Supports further study of Ren-2 in pre-hypertensive states; leaves open translation from transgenic rats to human disease.
Zhao et al. (1993) studied Hypertension. TGR(mREN2)27 transgenic rat model vs. DBA/2 mice and nontransgenic rats was evaluated on Ren-2 gene expression. Tissue-specific expression of the Ren-2 gene in TGR(mREN2)27 transgenic hypertensive rats was similar to DBA/2 mice, with expression in cardiovascular organs preceding the development of hypertension.
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