Population
Transgenic hypertensive rats, TGR(mREN2)27, and their adrenal cells
Design
Preclinical
Follow-up
60 minutes (for acute stimulation)
Authors
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Suggests adrenal RAS dysregulation contributes to hypertension in this model; leaves open relevance to human disease mechanisms.
The TGR(mREN2)27 rat model exhibits an activated adrenal renin-angiotensin system that lacks negative feedback by angiotensin II, highlighting its potential pathophysiological role in hypertension.
Peters et al. (1993) studied this question.
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