Why the study?
Does dexamethasone suppress hypertension development in the transgenic rat TGR(mREN2)27?
Population
Transgenic rat TGR(mREN2)27 (a monogenetic rat model in hypertension research) and Sprague-Dawley control rats
Comparison
Dexamethasone 100 micrograms/kg daily injection… vs Sprague-Dawley control rats receiving the same…
Design
Preclinical
Follow-up
8 weeks
Authors
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Supports ACTH-dependent steroids in transgenic rat hypertension; hypothesis-generating for human mechanisms.
Does dexamethasone suppress hypertension development in the transgenic rat TGR(mREN2)27?
ACTH-dependent steroids other than the mineralocorticoid aldosterone appear responsible for the development of hypertension in the transgenic rat TGR(mREN2)27.
Djavidani et al. (1995) studied this question.
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