Key result
Prenatal dexamethasone exposure in rats increased adult offspring systolic blood pressure (140.1 vs 128.6 mmHg; P=0.009) and reduced renal 11β-HSD2 expression.
Absolute Event Rate: 140.1% vs 128.6%
p-value: p=0.009
Prenatal glucocorticoid overexposure in rats induces salt-sensitive hypertension in adulthood, likely mediated by reduced renal 11β-HSD2 activity.
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May link prenatal glucocorticoids to adult hypertension via 11β-HSD2 in rats; leaves open human translation and clinical relevance.
Tang et al. (2010) studied Hypertension. Dexamethasone (DEX) vs. Vehicle was evaluated on Systolic blood pressure in adult offspring (p=0.009). Prenatal dexamethasone exposure in rats increased adult offspring systolic blood pressure (140.1 vs 128.6 mmHg; P=0.009) and reduced renal 11β-HSD2 expression.
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