Key result
Plasma angiotensinogen concentration in nephrectomized rats was 5-fold higher than in adrenalectomized rats, and mixing their plasmas increased renin activity due to increased angiotensinogen.
The study suggests that rat plasma prorenin is probably not activated within the circulation by a prorenin convertase from the kidney.
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Challenges assumption of kidney-derived prorenin convertase in rat circulation; leaves open human mechanisms and relevance.
Evans et al. (1990) studied this question. Bilateral nephrectomy and adrenalectomy vs. Control rats was evaluated on Plasma angiotensinogen concentration and renin activity. Plasma angiotensinogen concentration in nephrectomized rats was 5-fold higher than in adrenalectomized rats, and mixing their plasmas increased renin activity due to increased angiotensinogen.
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