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August 1, 1997Hypertension

Effect of Bilateral Nephrectomy on Active Renin, Angiotensinogen, and Renin Glycoforms in Plasma and Myocardium

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Why the study?

Does bilateral nephrectomy alter active renin, angiotensinogen, and renin glycoforms in plasma and myocardium in sodium-depleted rats?

Population

Sodium-depleted rats

Comparison

Bilateral nephrectomy (BNX) vs Control conditions

Design

Preclinical

Follow-up

48 hours

Authors

SKStephen A. KatzUniversity of MinnesotaJOJohn A. OpsahlAlberta Hospital EdmontonMLMary M. LunzerUniversity of Minnesota

Discussion

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Implication

Supports renal origin of cardiac renin in rats; hypothesis-generating for human cardiac renin-angiotensin regulation.

Key Points

  • The study aims to explore how bilateral nephrectomy affects active renin and angiotensinogen levels in plasma and myocardium.
  • Measured active renin and angiotensinogen in plasma and myocardium of sodium-depleted rats post-bilateral nephrectomy at multiple time points.
  • Analyzed differences in glycoform proportions of renin in plasma versus myocardial homogenates.
  • Utilized control conditions to compare findings and interpret the renin-angiotensin system dynamics.
  • Control myocardial renin concentration was 1.4 ng Ang I/g myocardium/hr and plasma renin at 6.7 ng Ang I/mL plasma/hr.
  • Plasma renin concentration increased significantly shortly after bilateral nephrectomy, contrasting with myocardial levels that fell to 15% of control values at 48 hours (p<0.001).
  • Myocardial angiotensinogen increased 12-fold post-surgery, while plasma angiotensinogen increased 3.5-fold, highlighting differential responses.

Structured PICO

Does bilateral nephrectomy alter active renin, angiotensinogen, and renin glycoforms in plasma and myocardium in sodium-depleted rats?

P
Population
Sodium-depleted rats
I
Intervention
Bilateral nephrectomy (BNX)
C
Comparator
Control conditions
O
Outcome
Active renin concentration, active renin glycoforms I through V, and angiotensinogen in plasma and left ventricular homogenatessurrogate

Most cardiac renin appears to be derived from plasma renin of renal origin, as myocardial renin concentration falls dramatically after bilateral nephrectomy.

Cite This Study

Katz et al. (1997) studied this question.

synapsesocial.com/papers/6a7037cd31a3df8243287cbehttps://doi.org/10.1161/01.hyp.30.2.259
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renin is not synthesized by cardiac and extrarenal vascular tissues. A review of experimental evidence.1994 · 181 citations
  2. 2Stretch-mediated activation of cardiac renin gene1994 · 45 citations
  3. 3Different production and decay rates of six renin forms isolated from rat plasma1986 · 13 citations
  4. 4Effect of acute and chronic losartan therapy on active and inactive renin and active renin glycoforms*1995 · 10 citations
  5. 5Absence of renin-like activity in rat aorta and microvessels.1983 · 38 citations