Population
Male Swiss (Ren-1, Ren-2) and female BALB/c (Ren-1) mice (n=11 and 12 for Swiss, n=5 and 6 for BALB/c)
Comparison
Binephrectomy and in vivo inhibition of residual… vs Baseline (before binephrectomy)
Design
Preclinical
Follow-up
24 hours
Authors
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Should not alter human hypertension management; extends kinetic models of angiotensinogen regulation in rodents.
Plasma angiotensin is maintained or increased following binephrectomy in mice, suggesting a kinetic regulation of angiotensinogen levels where Ang II production is limited by low substrate concentration.
Skinner et al. (1995) studied this question.
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