Key result
Baseline plasma renin concentration and activity are not systematically higher in mice with two renin genes compared to mice with one renin gene.
Why the study?
Does the presence of a second renin gene increase plasma renin levels in mice?
Population
Male mice strains possessing two renin genes and one renin gene
Comparison
Presence of two renin genes (Ren-1 and Ren-2) vs Presence of one renin gene (Ren-1)
Design
Preclinical
Authors
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Questions assumptions on renin gene dosage in mouse models; leaves open other strain-specific factors as primary drivers.
Does the presence of a second renin gene increase plasma renin levels in mice?
The presence of a second renin gene is not a major determinant of differences in plasma renin concentration between different mouse strains.
Hansen et al. (2004) studied Mice with one or two renin genes. Two renin genes vs. One renin gene was evaluated on Plasma renin concentration (PRC) and plasma renin activity (PRA). Baseline plasma renin concentration and activity are not systematically higher in mice with two renin genes compared to mice with one renin gene.
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