Population
One- and two-gene mouse strains
Comparison
Introduction of a Ren-1D transgene into a… vs Background strain containing only the Ren-1C…
Design
Preclinical
Authors
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Should not alter clinical renin management; leaves open whether cis-elements dictate human renin tissue specificity.
The highly homologous mouse renin genes Ren-1C and Ren-1D display different tissue-specific expression patterns due to inherent cis-acting DNA elements.
Miller et al. (1989) studied this question.
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