What question did this study set out to answer?

To investigate the evolutionary history, structural variation, and tissue-specific expression patterns of renin genes across inbred and wild-derived mouse strains.

November 1, 1984GeneticsOpen Access

Evolution and Variation of Renin Genes in Mice

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Authors

DDDouglas DickinsonBuffalo State University KGKenneth W. GrossRoswell Park Comprehensive Cancer Center NPNina PicciniRoswell Park Comprehensive Cancer Center

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Implication

Warrants caution selecting mouse strains for renin studies; leaves open translation to human cardiovascular genetics.

Key Points

To investigate the evolutionary history, structural variation, and tissue-specific expression patterns of renin genes across inbred and wild-derived mouse strains.
Analyzed renin gene structure, restriction site polymorphisms, and enzymatic activity in wild-derived mouse subpopulations.
Evaluated tissue-specific expression levels and thermal stability differences between Ren-1 and Ren-2 isozymes in submandibular gland and kidney tissues.
Ren-1 encodes a thermostable isozyme expressed at low levels in submandibular glands and kidneys, whereas Ren-2 encodes a thermolabile isozyme expressed predominantly at high levels in submandibular glands.
Identified restriction site polymorphisms and putative expression variants in wild-derived mice, supporting a renin gene duplication event prior to the divergence of Mus spretus 2.75 to 5.5 million years ago.

Cite This Study

Dickinson et al. (1984) studied this question.

synapsesocial.com/papers/6a7080ef26770c2b8de092bc https://doi.org/10.1093/genetics/108.3.651

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Evolution and Variation of Renin Genes in Mice

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Cite This Study

Evolution and Variation of Renin Genes in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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